Not all individuals with CLL have to have therapy. In spite of all current improvements, the iwCLL even now recommends watchful observation for patients with asymptomatic illness.86 This recommendation is based on at the least two randomized trials comparing observation to either chlorambucil monotherapy or fludarabine, cyclophosphamide and rituximab (FCR). https://douglasd085wdl2.plpwiki.com/user