Large glucose backlinks to dysfunctions of glucose uptake and catabolism and induces substantial oxidative strain, dysfunction of endothelial cells. Higher hypertension leads to cardiac and vascular injury. Central obesity is linked to maldistribution of free of charge fatty acid, overproduction of inflammatory molecules, and leptin resistance [21]. Springer Mother nature https://www.directivepublications.org/journal-of-cardiovascular-diseases/