Trimethoprim/sulfamethoxazole may perhaps inhibit the hepatic metabolism of phenytoin. Sulfamethoxazole/trimethoprim, given at a common clinical dosage, enhanced the phenytoin 50 percent-lifetime by 39% and lessened the phenytoin metabolic clearance rate by 27%. Trimethoprim blocks the production of tetrahydrofolic acid from dihydrofolic acid by binding to and reversibly inhibiting th... https://reidtjtbk.bloginder.com/24661188/facts-about-zotrim-weight-loss-revealed