Pretreatment with probenecid lowers the two the natriuresis and hyperreninemia made by Bumex. This antagonistic effect of probenecid on Bumex natriuresis just isn't as a result of a direct action on sodium excretion but is most likely secondary to its inhibitory effect on renal tubular secretion of bumetanide. Therefore, probenecid http://elliottpdpal.blogzag.com/20995774/new-step-by-step-map-for